Maria Basil MD, PhD University of Pennsylvania The Molecular Regulation of a Novel Distal Airway Progenitor in COPD

Glynnis Garry MD University of Texas Southwestern Medical Center-Dallas The Role for PHF7 in Adult Fibroblast to Cardiomyocyte Reprogramming

Sattar Khoshkhoo MD Harvard Medical School Developmental Origins and Molecular Mechanisms of Somatic Mutations in Mesial Temporal Lobe Epilepsy

Paulo Lizano MD, PhD Beth Israel Deaconess Medical Center Blood-Brain Barrier Disruption as a Biomarker for Early Course Psychosis: An In Vivo/Ex Vivo Investigation

Anish Mitra MD, PhD Stanford University Cognitive and Circuit Mechanisms Underlying Spontaneous Cortical States

Jacqueline Parchem MD University of Texas-Houston Health Science Center Maternal COVID-19 and Placental Mechanisms of Preeclampsia

Sheila Shanmugan MD, PhD University of Pennsylvania Using person-specific networks to uncover sex differences in vulnerability to internalizing symptoms

Diana Shi, MD Harvard Medical School Molecular Dynamics of Glioma Formation and DNA Damage Response by Mutant IDH1

Joelle Straehla MD Massachusetts Institute of Technology Biologic regulators: a paradigm shift for cancer nanomedicine

Brian Sweis MD, PhD Icahn School of Medicine at Mount Sinai Neuroeconomic investigation of the computational and molecular mechanisms underlying depression

Samuel Weinberg MD, PhD Northwestern University The Role of Dendritic Cell Metabolism in Regulating Adaptive Immune Responses

Samir Zaidi MD PhD Memorial Sloan-Kettering Cancer Center Reprogramming Drug Resistance in Cancer Cells

Alice Cheng, MD, PhD Stanford University Engineering a synthetic microbial community for research and treatment of Nonalcoholic steatohepatitis

Theodore George Drivas, MD, PhD University of Pennsylvania Discovering molecular and genetic mechanisms of ciliary signaling in common disease

William Allen Freed-Pastor, MD, PhD Harvard Medical School Overcoming T cell exclusion to augment immunotherapy in pancreatic cancer

Alexander Gitlin, MD, PhD Stanford University Insights from complex immune disorders: how an apoptotic caspase unleashes inflammation

Gil Hoftman, MD, PhD University of California-Los Angeles Imaging transcriptomics across developmental stages of early psychotic illness

William L Hwang, MD, PhD Harvard Medical School Identifying key regulators of the neuronal-like malignant phenotype and tumornerve crosstalk in pancreatic cancer

Maya Evelyn Kotas, MD, PhD University of California-San Francisco Understanding the role of tuft cells in allergic airway disease

Juan Carlos Osorio, MD Memorial Sloan-Kettering Cancer Center Optimization of Fc Effector Activity of Anti-CD47 Antibodies for Cancer Immunotherapy

Kartik Pattabiraman, MD, PhD Yale University Developmental disruption of prefrontal circuits as the neurodevelopmental etiology of schizophrenia

Jessica Renee Queen, MD, PhD Johns Hopkins University School of Medicine A Microbiota-Induced Switch to Immune Checkpoint Inhibitor Responsiveness in Colon Cancer

Carolyn Sangokoya, MD, PhD University of California-San Francisco Illuminating post-transcriptional control of stem cell fate and function

Jay Sarthy, MD, PhD Fred Hutchinson Cancer Research Center Interrogation of Pathological Histone Dynamics to Identify Drivers of Tumor Heterogeneity and Therapeutic Vulnerabilities

Christina Theodoris, MD, PhD Harvard Medical School Transfer learning leveraging large-scale single cell transcriptomics to enable predictions in settings with limited data

Josephine Wanjiru Thinwa, MD, PhD University of Texas Southwestern Medical Center-Dallas The Function of CDKL5 in autophagy and host antiviral defense

Serine Avagyan, MD, PhD Dana-Farber | Boston Children’s Hospital Cancer and Blood Disorders Center Hematopoietic stem cell clonal diversity in GATA2 deficiency associated blood disorders

David Benjamin Beck, MD, PhD National Institutes of Health (NIH)* Understanding the Role of Somatic Mutations in Severe Adult-Onset Inflammatory Diseases *Funding will be received by faculty institute TBD

Silvia Bernardi, MD Columbia University Neural bases of conceptual generalization and transfer learning: mechanisms that go awry in psychiatric illness

Jeeyeon Monica Cha, MD, PhD Vanderbilt University Understanding sexually dimorphic responses of the pancreatic beta cell in diabetes

Raghu Ram Chivukula, MD, PhD Massachusetts Institute of Technology Elucidating the Role of Lysosome Dysfunction in Pulmonary Fibrosis

Carlos Antonio Diaz-Balzac, MD, PhD University of Rochester Transcriptional regulation of neural circuit formation in intellectual disabilities

Neir Eshel, MD, PhD Stanford University Dopamine and serotonin at the intersection of reward and aggression

Russell Paul Goodman, MD, DPhil Massachusetts General Hospital Targeting Hepatic Reductive Stress to Treat Fatty Liver Disease

Brian Christopher Miller, MD, PhD Dana-Farber Cancer Institute Targeting Myeloid Cells as a Personalized Immunotherapy Approach to Cancer

Rachel Niec, MD, PhD Rockefeller University Lymphatic regulation of the intestinal stem cell niche

Celestine N. Wanjalla, MD, PhD Vanderbilt University Understanding the role of CD4+ T helper cells in cardiovascular disease progression in persons with HIV

Kevin Wei, MD, PhD Brigham and Women’s Hospital Notch3 as a therapeutic target in rheumatoid arthritisM

Alexander George Bick, MD, PhD Harvard Medical School Targeting clonal hematopoiesis using human genetics

Julia Catherine Carnevale, MD University of California-San Francisco Targeting SOCS1 and RASA2 to engineer more potent adoptive T cell therapies for cancer treatment

Erin Conrad, MD University of Pennsylvania Using EEG network alterations to diagnose epilepsy

Emily Anne Ferenczi, MB, ChB, PhD Harvard Medical School Direct projections from globus pallidus externa (GPe) to cortex: a novel role in basal ganglia-cortical circuit function

Ryan Alexander Flynn, MD, PhD Stanford University Defining the regulation of RNA by glycosylation

Anna Nam, MD  Weill Medical College of Cornell University Defining the impact of somatic mutations on human hematopoiesis via single-cell multi-omics

Josephine Ni, MD University of Pennsylvania Determinants of bacterial biofilm formation at the intestinal mucosal interface and their roles in pathogen exclusion

Xilma Rosa Ortiz-Gonzalez, MD, PhD University of Pennsylvania Looking at Neuroegenerative Disorders Through a Pediatric Lens

William Renthal, MD, PhD Harvard Medical School Leveraging single-cell genomics for the development of novel pain treatments

Andrew Ben Stergachis, MD, PhD  Harvard Medical School Single-molecule chromatin architectures of disease-associated non-coding genetic variants

Jonathan R Brestoff, MD, PhD Washington University Role of Cell-to-Cell Transfer of Mitochondria in Regulating Metabolism

Gaurav Das Gaiha, DPhil, MD Harvard Medical School Using Network Theory to Suppress the Latent HIV-1 Reservoir

Karuna Ganesh, MD, PhD Memorial Sloan-Kettering Cancer Center Emergence of Regenerative Plasticity in Metastasis Stem Cells

Wei Gu, MD, PhD University of California-San Francisco Modeling Pathogen Cell-free DNA Dynamics in Acute Infections

Marie A Guerraty, MD, PhD University of Pennsylvania The interplay between cardiomyocyte FOG2 and HIF pathway in Coronary Microvascular Disease

Rodney Infante, MD, PhD University of Texas Southwestern Medical Center-Dallas Regulation of Cancer Cachexia Wasting by a Tumor-Adipose-Hypothalamic Axis

Michael George Kattah, MD, PhD University of California-San Francisco A20 and ABIN-1 cooperatively preserve intestinal integrity

Corey Keller, MD, PhD Stanford University Closing the loop: development of real-time, personalized brain stimulation

Robert M Samstein, MD, PhD Memorial Sloan-Kettering Cancer Center Immunogenicity of Homologous Recombination Defects and Response to Immunotherapy

Ashley Steed, MD, PhD Washington University Regulation of Host Immunity via Microbially-derived Metabolites Santosha

Santosha A. Vardhana, MD, PhD Memorial Sloan-Kettering Cancer Center Investigating metabolic susceptibilities of exhausted T-cells

Andrew Sean Venteicher, MD, PhD University of Pittsburgh Uncovering drivers of immortality in human CNS tumors

Doris Du Wang, MD, PhD University of California-San Francisco Using adaptive neurostimulation to understand and enhance motor skill learning in Parkinson’s Disease

Samuel F Bakhoum, M.D., Ph.D. Memorial Sloan-Kettering Cancer Center Probing the role of chromosomal instability in tumor evolution

Elizabeth Joyce Bhoj, M.D., Ph.D. University of Pennsylvania A novel pediatric neurodegenerative disorder caused by histone 3.3 mutations: unique insights into the histone code

Hsiao-Tuan Chao, M.D., Ph.D. Baylor College of Medicine Mechanisms of COE-transcriptional dysfunction in neurodevelopmental disorders

Keira Alexis Cohen, M.D. Johns Hopkins University School of Medicine Genomic analysis of drug resistance determinants in nontuberculous mycobacteria

John Gordan, M.D., Ph.D. University of California-San Francisco Targeting viral mechanisms of oncogenesis in liver cancer

Sarah Emily Henrickson, M.D., Ph.D. University of Pennsylvania Directly interrogating mechanisms of human T cell dysfunction in the setting of chronic inflammation and atopy

Benjamin Izar, M.D., Ph.D. Harvard Medical School Functional validation of resistance mechanisms to immunotherapies at single-cell resolution

Corrine RaShelle Kliment, M.D., Ph.D. Johns Hopkins University The role of adenine nucleotide translocase in the protection of airway epithelial cells in Chronic Obstructive Pulmonary Disease (COPD)

Albert Russell Powers, M.D., Ph.D. Yale University School of Medicine Computational markers for psychosis:  toward early diagnosis and intervention

Deepak Angara Rao, M.D., Ph.D. Harvard Medical School Peripheral helper T cells in autoimmunity

Ansuman Satpathy, M.D., Ph.D. Stanford University Epigenetic mechanisms of immunotherapy resistance in tumor-specific T cells

Mark A Sellmyer, M.D., Ph.D. University of Pennsylvania Engineering digital logic for cell-cell interactions

Tanya Sippy, M.D., Ph.D. New York University Reward processing in striatal projection neurons during goal directed behaviors8

Vijay Garud Bhoj, M.D., Ph.D. University of Pennsylvania Development of CAR T-cell immunotherapy for prevention and eradication of FVIII inhibitors in Hemophilia A

Lindsay Catherine Burrage, M.D., Ph.D. Baylor College of Medicine Impaired glycogen metabolism and chronic liver disease in urea cycle disorders

Aaron Foster Carlin, M.D., Ph.D. University of California-San Diego Deciphering human innate immune responses to Zika virus infection

Alejandro Chavez, M.D., Ph.D. Harvard Medical School Novel technologies and their application to neurodegenerative diseases

Whitney Elizabeth Harrington, M.D., Ph.D. University of Washington Defining the role of maternal cells in fetal and infant immunity to malaria

Tamia Alisha Harris-Tryon, M.D., Ph.D. University of Texas Southwestern Medical Center-Dallas The Function of Resistin Like Molecule alpha (RELMalpha) in Cutaneous Host Defense

Kara Noelle Maxwell, M.D., Ph.D. University of Pennsylvania A genotype-phenotype study of tumors from patients with inherited mutations in DNA repair genes

Kent William Mouw, M.D., Ph.D. Harvard Medical School Investigating the effect of ERCC2 mutations on DNA repair capacity and chemo-radiotherapy response in muscle-invasive bladder cancer

Anoop Patel, M.D. University of Washington Deep interrogation and modeling of intratumoral heterogeneity, plasticity, and tumor evolution in glioblastoma

Tamer Sallam, M.D., Ph.D. University of California-Los Angeles Spatial control of nuclear receptor regulatory circuits in cardiovascular disease

Zuzana Tothova, M.D., Ph.D. Harvard Medical School Elucidating the mechanisms of cohesinopathy in myelodysplastic syndromes

Craig Brian Wilen, M.D., Ph.D. Washington University Role of virus-receptor interactions in determining norovirus tropism and pathogenesis

Jonathan Abraham, M.D., Ph.D. Harvard Medical School Profiling the human antibody response in survivors of viral hemorrhagic fevers

Heidi Leigh Cook-Andersen, M.D., Ph.D. University of California-San Diego Post-transcriptional gene regulation during the mammalian oocyte-to-embryo transition

Mariella Gruber Filbin, M.D., Ph.D. Harvard Medical School Discovering novel epigenetic dependencies in pediatric high-grade glioma

Andrew Michael Intlekofer, M.D., Ph.D. Memorial Sloan-Kettering Cancer Center Investigating L-2-hydroxyglutarate production and its relevance to normal hematopoiesis and leukemogenesis

Siddhartha Jaiswal, M.D., Ph.D. Harvard Medical School Elaborating the causal link between clonal hematopoiesis and atherosclerosis

Devanand Sadanand Manoli, M.D., Ph.D. University of California-San Francisco Genetic models of social attachment in development and mental illness

Alexander Marson, M.D., Ph.D. University of California-San Francisco Molecular characterization of non-coding genetic variants that promote human autoimmunity

Seth Rakoff-Nahoum, M.D., Ph.D. Harvard Medical School Gut microbiota ecological interaction networks in health and disease

Dhakshin Ramanathan, M.D., Ph.D. University of California-San Francisco Role of spindle oscillations in modulating neural plasticity and procedural memory consolidation

Tiffany Crawford Scharschmidt, M.D. University of California-San Francisco Elucidating mechanisms of immune tolerance to skin commensal bacteria

Alexander Spektor, M.D., Ph.D. Harvard Medical School The mechanism of DNA damage and chromothripsis from chromosome segregation errors

Bruce Mao Zheng Wang, M.D. University of California-San Francisco Wnt signaling and hepatocyte stem cells in liver homeostasis and cancer

Jennifer M Alexander-Brett, M.D., Ph.D. Washington University Targeting the Regulatory Mechanism of the Nucleokine IL-33

Daniel Evan Bauer, M.D., Ph.D. Harvard Medical School Functional Characterization of Trait-Associated Enhancers

James Toliver Bennett, M.D., Ph.D. University of Washington Impact of Somatic Mutations on Birth Defects

Shadmehr Demehri, M.D., Ph.D. Harvard Medical School Local and Systemic Effects of TSLP on Cancer

Charles Gawad, M.D. University  of Tennessee Health Science Center College of Medicine Defining the Cellular and Genetic Origins of Childhood Acute Lymphoblastic Leukemia using Single-Cell Genomics

Matthew Blake Greenblatt, M.D., Ph.D. Weill Cornell Medical College Novel Mechanisms of Bone Formation

Rajan Jain, M.D. University of Pennsylvania Perelman School of Medicine Nuclear lamina-chromatin interactions are drivers of cardiac progenitor cell commitment

Matthew Stern Kayser, M.D., Ph.D. University of Pennsylvania Perelman School of Medicine A role for sleep in synapse development and susceptibility to neuropsychiatric disorders

Dan Avi Landau, M.D., Ph.D. Weill Cornell Medical College Genetic and Epigenetic Determinants of Chronic Lymphocytic Leukemia Evolution

Kory Joshua Lavine, M.D., Ph.D. Washington University School of Medicine Distinct Macrophage Lineages Govern Cardiac Recovery and Heart Failure Progression

Bluma J. Lesch, M.D., Ph.D. Massachusetts Institute of Technology Evolutionary and functional characterization of poised chromatin in the mammalian germ line

Joseph Douglas Mancias, M.D., Ph.D. Harvard Medical School Role of ferritinophagy in iron metabolism and pancreatic cancer

Anna Victoria Rotberg Molofsky, M.D., Ph.D. University of California-San Francisco Astrocyte-Encoded Regional cues in Developmental Synapse Formation

Theresa Alenghat, D.V.M., Ph.D. University of Cincinnati Epigenomic regulation of the host-commensal relationship

Christina Eleanor Barkauskas, M.D. Duke University Epithelial-mesenchymal crosstalk in lung fibrosis and alveolar homeostasis

James Edward Cassat, M.D., Ph.D. Vanderbilt University School of Medicine The contribution of host and pathogen to altered bone homeostasis and bacterial survival during osteomyelitis

Kevin Jon Cheung, M.D. Johns Hopkins University Elucidating the role of K14+ leader cells in breast cancer invasion and metastasis

Ethan Michael Goldberg, M.D., Ph.D. University of Pennsylvania Perelman School of Medicine Analysis of circuit function informs novel therapeutic interventions in an epilepsy model

Malay Haldar, M.D., Ph.D. Washington University School of Medicine Transcription factor SPI-C at the interface of iron homeostasis and innate immunity

Marcin Imielinski, M.D., Ph.D. Harvard Medical School Reconstructing complex loci in lung adenocarcinoma with large-insert whole genome sequencing

Jeffery M Klco, M.D., Ph.D. University of Tennessee Role of notch signaling in the bone marrow stroma

Jason Knight, M.D., Ph.D. University of Michigan-Ann Arbor Innate immunity in the pathogenesis of lupus and antiphospholipid vasculopathy

Anita Katherine McElroy, M.D., Ph.D. Emory University School of Medicine Defining the roles of CD4+ T cells in generating a protective immune response against Rift Valley fever virus

Sudarshan Rajagopal, M.D., Ph.D. Duke University Medical Center Dissecting receptor Signaling pathways in pulmonary hypertension

Sean Robinson Stowell, M.D., Ph.D. Emory University School of Medicine Elucidating mechanisms of innate immunity against molecular mimicry

Susanne Elizabeth Ahmari, M.D., Ph.D. Columbia University Testing the Role of Cortico-Striatal Circuits in Obsessive Compulsive Disorder Pathology and Treatment

Gautam Bhave, M.D., Ph.D. Vanderbilt University Medical Center Role of Peroxidasin and Protein Halogenation in Diabetic Nephropathy

Ajai Arvind Dandekar, M.D., Ph.D. University of Washington Quorum sensing and mechanisms to ensure cooperation in the opportunistic pathogen Pseudomonas aeruginosa

Andrew Eugene Hermann Elia, M.D., Ph.D. Harvard Medical School Proteomic analysis of ubiquitination and protein stability in the DNA damage response

Gaorav P Gupta, M.D., Ph.D. Memorial Sloan-Kettering Cancer Center DNA Damage Responses in Breast Cancer Pathogenesis

Andrew Caleb Hsieh, M.D. University of California-San Francisco Elucidating the role of aberrant translational control on prostate cancer invasion and metastasis

Jean-Sebastien Joyal, M.D., Ph.D. University of Montreal Faculty of Medicine Neuronal Energy Metabolism Drives Angiogenesis

Alex Kentsis, M.D., Ph.D. Harvard Medical School Tumorigenesis by endogenous DNA transposons in human cancer.

Jeniel Emily Nett, M.D., Ph.D. University of Wisconsin-Madison Mechanisms of Candida Biofilm Immune Evasion

Rhea Myers Sumpter, Jr., M.D., Ph.D. University of Texas Southwestern Medical Center-Dallas A novel role for FANCC in selective autophagy

Chetan Bettegowda, M.D., Ph.D. Johns Hopkins University Translational molecular profiling of oligodendrogliomas

Scott Richard Floyd, M.D., Ph.D. Massachusetts Institute of Technology Insulating chromatin from DNA damage signaling: epigenetic modifications and connections to human cancer

Benjamin Elison Gewurz, M.D., Ph.D. Harvard Medical School Identification of novel NFkB pathway components important for lymphomagenesis

Michael Rosenblum, M.D., Ph.D. University of California-San Francisco Memory regulatory T cells in inflammatory and autoimmune disease

Michael Thomas Spiotto, M.D., Ph.D. University of Chicago Identification of chromosomal aberrations that cooperate with the human papillomavirus to cause cancer

David Tsai Ting, M.D. Harvard Medical School Characterization of non-coding RNAs in pancreatic adenocarcinoma

Richard Chih-Chien Wang, M.D., Ph.D. University of Texas Southwestern Medical Center-Dallas Akt-mediated regulation of autophagy & tumorigenesis through formation of a beclin 1/keratin intermediate filament complex

Kelley Yan, M.D., Ph.D. Stanford University Regulation of active and quiescent intestinal stem cells

Ellen Yeh, M.D., Ph.D. Stanford University Function of the plastid organelle in P. falciparum: beyond isoprenoid precursor biosynthesis and blood stage

Hao Zhu, M.D. Harvard University Investigating the Lin28/let-7 pathway in mouse models of liver cancer and regeneration